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Shaik Afsar Pasha*, Ch. Bhuvana, V. Kumudini, R.Haribabu, SK. Arif Pasha, B.Bhaskara Rao


Background: Polypharmacy often with propensity to cause serious adverse drug interactions is common phenomenon in many developing countries, including in India. This phenomenon can be extremely harmful in patients with stroke, as few combinations significantly increase the risk of reccurent stroke. Hence drug utilization study using prescribing indicators enables us to detect and also to quantify problems in prescribing practices. Objectives: 1. To study the drug prescribing pattern among stoke patients and the indications for which they have prescribed. 2. To Determine the average drug encounter per prescription 3. To analyze the conformity of the drug usage pattern with WHO indicators and standard treatment guidelines. Materials and Methods: Study design: The current study was a prospective observational study of stroke patients presented to the department of neurology and emergency, NRI medical college, Hospital, Chinakakani, located in Guntur, Andhra Pradesh. The data collection for the study was conducted between October 2016 to December 2016. Data on demographic parameters, drug prescription pattern and clinical profile was documented in a structured proforma. Results: There was high proportion of polypharmacy among the study population. There were about 8.5% of the people who were taking more than 19 medications. The proportion of subjects who were taking 16 to 18, 13 to 15 and 10 to 12 medications were 16.19%, 14.28% and 26.67%. About 28.57% of the patients were taking 7 to 9 medications and 7.61% of the subjects were taking 4 to 6 medications. The most common categories of the drugs being consumed were antiplatelet drugs (82.8%), followed by Anti-ulcer medication (75.2%) and Antihypertensive (74.25). Among the antiplatelet drugs, 21.9% were taking aspirin alone, 1.9% were taking clopidogrel alone and remaining 73.3% were taking both aspirin and clopidogrel. Conclusions: The study findings suggest that high proportion of stroke patients are on polypharmacy. Regular audit of the prescribing pattern and monitoring the patients may prevent serious Adverse drug reactions (ADR`s).

Keywords: Stroke, prescription pattern, polypharmacy.

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