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Vishin Ashish Patil* and Sachin Annasaheb Nitave


Throughout the world, there has been an increasing incidence of bacterial infections and because of drug resistance and toxicity associated with long-term treatment with antibacterial drugs, search for new drugs to treat bacterial infections is ongoing. The aim of the present study was to formulate polyherbal antibacterial cream and evaluate its physicochemical properties and stability. To select the best cream formulation, one general formula of cleansing cream was considered and then corrected. The best base formula was chosen according to its monotonousness, straightness and external attractiveness. The formulation containing the plant extract of Psidium guajava, Luffa acutangula and Curcuma aromatica was prepared. Finally, a cream containing stearic acid, triethanolamine, liquid paraffin, propylene glycol, cetostearyl alcohol, methyl paraben, propyl paraben and water was chosen as the best formulation. The final product was a o/w emulsion cream with suitable appearance and desirable physicochemical stability. Due to the stability of the extract in the cream formulation, it was formulated for treatment of bacterial skin infections.

Keywords: Psidium guajava, Luffa acutangula, Curcuma aromatica, cream, polyherbal.

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