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Abstract

DEVELOPMENT OF CONTROLLED RELEASE MUCOADHESIVE TABLETS OF CLARITHROMYCIN USING NATURAL POLYSACCHARIDE

Nishad K. M.* and B. Arul

ABSTRACT

The present investigation was to formulate controlled release of mucoadhesive tablets. The tablets were formulated by using clarithromycin as drug. Which is a semi synthetic macrolide antibiotic for the treatment of H. pylori infection in peptic ulcer. The releases of drug were controlled by polymers of natural polysaccharide like chitosan and tamarind seed polysaccharide. which is isolated from the seeds of Tamarindus indica. The combined form of these polymers with drug was formulated to once daily controlled release mucoadhesive tablets. The excipients were subjected to preformulation studies including FTIR compatibility studies. The tablets were evaluated for in-process and in-vitro studies. The biosdhesive strength of tablets and polymers were determined by different ex-vivo methods via HPMC K-100 comparitative study. The selected formulations were subjected to stability studies. The study concluded that combination of chitosan and TSP is best natural polymer for mucoadhesion by the advantages of controlled release and biodegradation.

Keywords: Clarithromycin. Mucoadhesion, Tamarind seed polysaccharide-Chitosan, HPMC K-100, ex-vivo methods.


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