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            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF IN VITRO CYTOTOXIC, ANTIBACTERIAL, ANTIOXIDANT ACTIVITY AND MOLECULAR DOCKING STUDIES OF NITRO SUBSTITUTED BENZOXAZOLE LINKED THIAZOLIDINE DERIVATIVES

S. H. Shreedhara, H. M. Vagdevi*, N. D. Jayanna, R. Raghavendra, A. Subbaraju

ABSTRACT

The 3-[(6-nitro-1,3-benzoxazol-2-yl)amino]-2-phenyl-1,3-thiazolidin-
4-one derivatives 6(a-j) have been synthesized by reacting compounds
2-[2-benzylidenehydrazinyl]-6-nitro-1,3-benzoxazole derivatives 5(a-j)
with thioacetic acid in dioxane using ZnCl2 as catalyst. The chemical
structures of the compounds were elucidated by IR, 1H NMR, 13C
NMR and Mass spectral studies. The organisms such as Escherichia
coli (ATTC-8739), Staphylococcus aureus (ATTC-6538), Vibrio
cholera (ATTC-9027), Bacillus subtilis (ATTC-6633), Staphylococcus
epidermidis (ATTC-12228) and Salmonella typhimurium (ATTC-
23564) have been used to study the antimicrobial activity of
synthesized compounds. MIC was done with effective result, the
selected synthesized derivatives showed potent cytotoxic activity against Peripheral Blood
Mononuclear cancer Cells. The antioxidant activity has been carried out to know the
scavenging effect of targeted molecules and the results were supported by the in silico
molecular docking studies.

Keywords: Benzoxazole, Schiff base, thioacetic acid, thiozolidinine, Peripheral Blood Mononuclear Cells.


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