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Abstract

ENHANCEMENT EFFECT OF CUO NANOPARTICLES FOR DETERMINATION OF LEVETIRACETAM USING LUMINESCENCE METHODS: COMPARATIVE STUDIES SPECTROFLUORIMETRY AND CHEMILUMINESCENCE DETECTIONS

Maha F. El-Tohamy* and Abdulkareem Abdulraheem

ABSTRACT

The present work focused on the enhancement effect of CuO nanoparticles (CuONPs) on luminescence detection of anticonvulsant drug levetiracetam (LCM). The main strategy of this study is the synthesis and characterization of CuONPs using copper acetate and glacial acetic acid in the presence of alkaline medium sodium hydroxide at 80ºC. Also, the enhancement effect of CuONPs was tested using two developed luminescence detection systems, CuONPs- LCM complex and luminol-H2O2- CuONPs-LCM as fluorescence (FL) and sequential injection chemiluminescence analysis (SIA-CL) systems, respectively. Under optimum conditions the fluorescence intensity was recorded at λem 438 nm after λex 350 nm and a linear relationship was plotted over the drug concentrations of 1.0×10-8-1.0×10-2 mol L-1, (n = 7, r = 0.999) with limit of detection 2.5×10- 9 mol L-1. While, the SIA-CL system enables the detection of LCM over the concentration range of 1.0×10-10- 1.0×10-2 mol L-1 (n = 9, r = 0.999), with detection limit 1.7×10-11 mol L-1. The proposed methods were shown to be highly sensitive for determination of the selected drug in different samples such as bulk powder, tablets and bio-samples. To ensure the suitability of the developed methods, full validation and statistical treatment of data were applied.

Keywords: Levetiracetam; Chemiluminescence; Fluorescence; CuO nanoparticles; Bio-samples.


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