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G. Venkata Ramana* and T. Mangilal


Recently, many drugs have been formulated as floating drug delivery systems with an objective to sustain release and restrict the region of drug release to stomach. The purpose of the investigation was to prepare a gastro retentive drug delivery system of Amoxicillin. Amoxicillin is a Semi synthetic antibiotic, belonging Beta-lactum family, which is effective for bacterial treatment, especially for helicobacter pylori infection. Different formulations were formulated using various concentrations of Guar gum and Ethyl Cellulose. All the formulations were evaluated for physico-chemical parameter like weight variation, thickness, hardness, friability, drug content, swelling index, floating lag time and in-vitro drug release. In-vitro drug release data was treated according to Zero, First, Korsemeyer-Peppa’s and Higuchi’s kinetics to access the mechanism of drug release. On the basis of in-vitro release studies & physico-chemical parameters, the formulation F7 with 30% of Guar gum, 5% ethyl cellulose and 15% NaHCO3 sustained drug release with maximum cumulative of 98.79% for a period of 12h and it was found to be better than other formulations, hence F7 was selected as optimized formulation. The main aim was to optimize the formulation for 12 hrs in‐vitro drug release with the use of polymer.

Keywords: Amoxicillin, Floating tablets, Gastro retentive, Guar gum.

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