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Abstract

A PHARMACOLOGICAL EVALUATION OF ANTI-DIARRHEAL ACTIVITY OF AQUEOUS LEAVES EXTRACT OF PHYLLANTHUS AMARUS IN EXPERIMENTALLY INDUCED DIARRHEA IN RATS

Suchita Singh Chauhan, Hemant Kumar Sharma

ABSTRACT

Objective: To investigate anti-diarrheal potential of aqueous leaves
extract of Phyllanthus amarus (P. amarus) by castor oil induced
diarrhea, charcoal meal test and PGE2 induced diarrhea in mice.
Methods: The test group received various doses (100, 200 and 400
mg/kg) of the aqueous extract, whereas positive control (standard)
Atropine. Albino wistar rats (150-200g) of either sex were used for the
study. Results: Preliminary phytochemical screening revealed that
presence of tannins, glycosides and alkaloids. The intraperitoneal LD50
of the extract was found to be at doses of 5, 50, 300 and 2000 produced
no mortality or apparent toxic signs. Aqueous extract of P. amarus
exhibited a concentration-dependent action of castor oil induced
diarrhea. The result suggested could act centrally and inhibit the PGE2
to give anti-diarrheal effects. Results of charcoal meal test also
suggested its anti-muscarinic activity. Conclusions: These finding
suggest that aqueous extract of P. amarus remarkable effect in the treatment of diarrhea,
corroborating to folk use of P. amarus preparation and contribution for its pharmacological
validation.

Keywords: Phyllanthus amarus, castor oil, Diarrhea, Charcoal meal, PGE2.


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