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Abstract

DEVELOPMENT AND VALIDATION OF A UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF NAPROXEN AND SUMATRIPTAN

*Vernekar Saumya and Dr. Theivendren Panneerselvam

ABSTRACT

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for reduction of moderate to severe pain, fever, inflammation and stiffness. Sumatriptan is a 5HT agonist. Acting as an agonist at these receptors, Sumatriptan reduces the vascular inflammation associated with migraines. The objective of the present work was to develop and validate a simple UV method for simultaneous estimation of Naproxen and Sumatriptan in combined dosage form.Q Absorption ratio method was used for calculation of assay results. Methanol and Phosphate buffer pH 6.8 (50:50 v/v) was used as a diluent. The developed method was validated according to ICH guidelines and found to be specific, accurate, precise and robust. Assay of the formulation was performed and the mean assay values were found to be within acceptable limits. These methods can also be used to estimate NAP and SUM as independent components. The developed methods are cost effective, time saving, simple and precise.

Keywords: Naproxen, Sumatriptan, UV method, Q Absorption Ratio method.


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