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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

GREEN SYNTHESIS OF GOLD NANOPARTICLES USING LEAF EXTRACT OF GARCINIA COMBOGIA, ITS GENOTOXIC EFFECTS ON E.COLI DNA AND CYTOTOXIC EFFECTS ON HE LA CELL LINES.

B. Nithya* and A. Jayachitra

ABSTRACT

Cancer is a mortiferous disease or a destructive phenomenon emerges
in human beings as a result of genetic factors or disclosure to harmful
chemicals or viral infections etc. Compared to other treatments Radio
therapy is potential in the treatment of cancer. In this therapy, despite
the normal cells are also disintegrated in the fore with tumor cells.
Nanomedicine is a relavent treatment of cancer is an innovative
landing. Progressing consignment of anticancer agents to tumors using
nanoparticles is one of the most protrusive combat zone in the research
field of nanotechnology. It can be known from research that MTT
assay is broadly applied and extensively approved method in finding
invitro anticancer activity of metal nanoparticles. Gold nanoparticles biosynthesis is
upsurging from day to day generating an upshot in all biological applications. Green
synthesized gold nanoparticle inhibit the proliferation of cancer cells by activating the
apoptosis process or changing the cellular chemistry. Present investigation reveal the gold
nanoparticles biosynthesizing capability of the leaf of Garcinia combogia. Newly genre gold
nanoparticles were characterized by involving UV–vis spectroscopy, FTIR, XRD, SEM,
analysis. Strikingly as a result of extensive screening on the application of newly synthesized
gold nanoparticles their anticancer cytotoxicity has been discovered using MTT assay and its
genotoxicity by DNA fragmentation.

Keywords: Garcinia combogia, Gold nanoparticles, MTTassay, DNA fragmentation.


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