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Abstract

OXAZINO [2, 3-A] ISOQUINOLINES: POTENTIAL DENGUE VIRUS PROTEASE INHIBITORS IN SILICO APPROACH

Prasanna B. Ranade, Dinesh N. Navale, Santosh W. Zote and M. M. V. Ramana*

ABSTRACT

Dengue, a viral disease presently having neither effective antiviral chemotherapy nor approved vaccine. Therefore, designing new scaffolds against dengue virus replication is an important aspect for researchers. Tetracyclic compounds were known to exhibit antidengue activity. Hence we perform the docking studies on designed tetracyclic derivative, oxazino [2, 3-a] isoquinolines against dengue virus NS2B/NS3 protease. The hydrogen bonding, hydrophobic interactions and Van der Waals forces between designed compounds with Lys74, Trp83, and Leu149 amino acid residues of the NS2B/NS3 protease is also discussed.

Keywords: Oxazino [2, 3-a] isoquinolines, Dengue Virus Protease, Docking, ADME prediction.


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