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Abstract

MICROWAVE ASSISTED SYNTHESIS AND CHARACTERIZATIONS OF ZN (II) METAL COMPLEX WITH BIO-ACTIVE ISONIAZID AND BENZOATE IONS

P. Manikandan*, K. Rajasekar, S. Balasubramaniyan, T. Gomadurai and B. Sathiyamoorthy

ABSTRACT

Transition metal complex of Zn (II) has been synthesized with the Isoniazid and benzoate ion ligands by microwave assisted technique. The synthesized complex was characterized by elemental analysis, metal estimation, molar conductance and spectral studies viz., UV, IR, and NMR. The ligand Isoniazid behaves as neutral, bidentate and forms coordinate bonds through O and N atoms. From the results of elemental analysis and metal estimation, the Zn(II) forms complex of [ML(Benz)2] type stoichiometry. The tetrahedral structures of the synthesized complex were confirmed by the UV-spectral data. Complexation and metal chelate were confirmed by the IR and far-IR spectral studies and the structure also confirmed from their NMR spectral studies. The redox properties of the ligand and its complex were briefly investigated by electrochemical manner using cyclic voltammetry (CV). The antibacterial strains Actinobacter and Salmonella typhi, antifungal strains Aspergillus Niger of the metal complex were evaluated and compared with those for pure INH.

Keywords: Isoniazid, Zn (II) complex, benzoate ion, antibacterial, antifungal activity, cyclic voltammetry.


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