WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Talat Farheen*, Azmat Shaikh and Dr. Sadhana Shahi


Microspheres were found to be more efficient for controlled drug delivery systems, further the mucoadhesion provides feature of targeted drug delivery to the dosage form. Mucoadhesion ensures increased contact time of the dosage form with the absorption site while microspheres sustained the release of drug from the dosage form at the site of absorption and result into improved bioavailability of drug. The objective of the present research is to formulate mucoadhesive microspheres of saxagliptin, to achieve reduced dosing frequency, increased bioavailability, increased patient compliance and decreased drug related adverse effects. This objective is achieved by formulating the mucoadhesive microspheres of the drug using orifice ionotropic gelation technique. Sodium alginate is used as a polymer while calcium chloride as counterion and HPMC K4M as mucoadhesive polymer. The formulation batches were prepared by 32 factorial design and evaluated for particle size, flow properties, mucoadhesion, microencapsulation efficiency, drug release and stability. The formulation SF6 showed nearly spherical microcapsules, good flowability, microencapsulation efficiency, mucoadhesion, stability and extended drug release upto 12 hours. An approach to develop a stable mucoadhesive microspheres of oral hypoglycemic drug, Saxagliptin has been successfully achieved.

Keywords: Orifice ionotropic gellation, Sodium alginate, CaCl2, HPMC K4M.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More