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Abstract

AN INSIGHT OF THE ROLE OF VITAMIN D ON SKIN DISEASES

Gadah Abdulatif Alhosawi*

ABSTRACT

Vitamin D is one of the most essential hormones in the human body which is produced by epidermal keratinocytes under the effect of the sun’s radiation {Ultraviolet B}. Further, 25{OH}2D3 is the inactive form of vitamin D that helps physicians investigate the serum level of vitamin D and determine whether an individual has an insufficient amount of this hormone or is deficient. The other form of vitamin D, 1,25{OH}2D, which is the active type, is more likely to have pleiotropic actions on different parts of the body: it regulates the growth of epidermal keratinocytes and cell proliferation and differentiation; also, vitamin D could functions as an immunomodulator especially in the cases of autoinflammatory diseases, for instance, atopic dermatitis, psoriasis, and alopecia areata. Basically, the immune response of vitamin D to such skin conditions involves the promotion T regulatory cells and production of IL-10, which controls the response of T helper cell proliferation; inhibits the release of IL-2, IL-17, IL-8, and interferon-γ; and enhances the functioning of the antigenpresenting cells. Besides that, an obvious role of 1,25{OH}2D on some elements such as calcium and phosphate, both of them are tend to be absorbed through the intestine secondary to the action of vitamin D receptor with vitamin D itself. Evidences show that the serum concentration of vitamin D to some extent affects the severity of some skin diseases. Accordingly, distinct clinical and laboratory trials have been conducted in order to address the therapeutic impact of this hormone on the patients, either to underline the safety of the vitamin D as a medication.

Keywords: Vitamin D, 1,25[OH]2D, Skin, Atopic dermatitis, Psoriasis, Alopecia Areata.


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