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Abstract

EFFECT OF COCCINIA INDICA EXTRACT FRUIT AND LEAF ON DIABETIC NEUROPATHY PAIN IN RATS

Somnath Kharwar*, Prof. (Dr.) B. B. Panigrahi, Md. Quammudin, Balwan Singh and Khalid Iqbal

ABSTRACT

We investigated the effect of freshly prepared chloroform extract of
cocciniaindica fruit and leaf extracton neuropathic pain, blood glucose
level and loss of body weight in hyperglycaemic rats. Streptozotocin
(STZ; 60 mg/kg, IP) was injected to albino rats to induce diabetes. Oral
administration of freshly prepared chloroform extracts to each of the
animal was given to STZ-induced diabetic rats until 7 weeks after the
STZ injection at a dosage of 500 mg/kg/day and 250 mg/kg/day The
glucose level test to follow the changes in blood glucose and body
weight measurement to evaluate loss of body weight in diabetic rats.
The pain evaluated by stimuli thermal: warm immersion (52+2) and
cold immersion test (100C) and paw withdrawal on Eddy’s hot plate
(45-52 +2) in diabetics rats. Treatment with these freshly prepared fruit and leaf chloroform
extract significantly reduced blood glucose and pain in diabetic rats. Blood glucose lowering
effect and analgesic activity of cocciniaindica decreased the pain in STZ- diabetic rats. STZinduced
loss of body weight was attenuated by the chloroform extract of the cocciniaindica.
The higher dose (500 mg/kg/day) of chloroform extract of the cocciniaindica therapy work
better than that of lower dose (250 mg/kg/day) against hyperglycaemia and painful
neutopathy in STZ-induced diabetes rats. Therefore the use of these plants as analgesic and
antidiabetic is justified. The rosiglitazone (10 mg/kg/day) also knows as thiazolidinediones is
an antidiabetic drug. In other member class of medication known as pioglitazone. It is used as
a standard drug and maintains the glucose level and diabetic neuropathic pain in diabetic rats.

Keywords: Cocciniaindica, rosiglitazone, analgesic, hyperglyceamia,body weight, STZ-induced diabetic rats.


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