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Abstract

SECOND TRIMESTER MATERNAL SERUM BETA HCG LEVEL AS A PREDICTOR OF PREGNANCY INDUCED HYPERTENSION

Dr. Asha Sadanand Joshi,* Dr. Kanchan Kunal Joshi, Dr. Sadanand Balkrushna Joshi, Dr. Kunal Sadanand Joshi

ABSTRACT

Objective: To test the hypothesis that women with high serum beta-HCG levels in early pregnancy are at higher risk of developing PIH. Methods: Serum beta-HCG estimation was done by CLIA method in 400 women between 13 and 20 weeks of gestation, from Jan 2015 to March 2017. Multiple of median (MOM) was calculated from charts of norms available for that week of pregnancy. They were followed till delivery for development of PIH and pregnancy outcome and results analysed statistically with Chi-square test. Results: Out of 400 cases, 356 (89%) were finally evaluated. Of whom 44(12.36%) cases developed PIH. Beta HCG levels were considered raised if the levels were >2MOM. 40 (83.33%) out of 48 cases with beta HCG levels >2MOM developed PIH against 4 (1.2%) cases out of 308 having beta HCG levels ≤2 MOM (P value<0.001). Also, higher levels of beta HCG are associated with increased severity of PIH (P value<0.01). The sensitivity was 90.91%, specificity was 97.44% and positive predictive value was 83.33%. Conclusion: The study concluded that the serum beta HCG estimation at mid trimester (13–20 weeks) is a good predictor of PIH and higher levels of beta HCG are associated with increased severity of PIH.

Keywords: Beta HCG, Pregnancy Induced Hypertension (PIH).


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