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Abstract

FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS WITH ANTIHYPERTENSIVE DRUG

Ritesh Suresh Bathe*, Girendra Kumar Gautam and Reni Kapoor

ABSTRACT

Transdermal therapeutic systems were studied applying different ratios of polymer HPMCK15M, (PVPK30) polyvinyl pyrrolidone and ethyl cellulose was added in the formulation as pore creating agent for improvement of bioavailability of drug and reducing toxic effects. Dibutyl phthalate and PEG-400 were used as plasticizer and tween 80 and DMSO were used as penetration enhancer. Solvent evaporation method was used for the formulation of patches. The patches showed satisfactory folding endurance and tensile strength and it indicated good physical stability. The drug-excipients compatibility studies were performed by Infrared spectrophotometer (IR). Transdermal permeation of carvedilol through rat abdominal skin was determined by using modified Franz diffusion cells and formulation F4 and F5 showed 93.00%, 92.05% drug release at the end of 24 hours. Release kinetics studies revealed that the drug release from formulation F4 and F5 followed Higuchi kinetics with release exponent value n=0.2, 0.28 which shows that release pattern of patches follows diffusion mechanism.

Keywords: Carvedilol, Matrix type transdermal patch, PVPK30, Ethyl cellulose, HPMCK15M, PEG-400, Release kinetics.


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