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Abstract

DISSOLUTION KINETICS OF IMMEDIATE RELEASE MINITABLETS OF CEFUROXIME AXETIL

Korlapati Venkateswara Rao* and V. V. Venkatchalam

ABSTRACT

The underlying principle of this research is to design the formulation and characterization of in vitro drug release of an immediate release mini-tablets of cefuroxime axetil. In order to get improved solubility and dissolution rate of cefuroxime axetil in gastrointestinal fluid, the hydrophilic grade of Gelucire 50/13, Poloxamer 188 and Sylysia 350 were used as release modifiers. Initially ten formulations (F1-F10) were prepared by direct compression technique and evaluated the physicochemical properties, in vitro dissolution study and their drug release kinetics parameters. The X-RD pattern specifies its amorphous nature, while Gelucire-50/13 exhibits a semi-crystalline nature. Gelucire 50/13, Poloxamer 188 and Sylysia 350 were typically applicable for the preparation of fast-release formulations. Sylysia 350 based formulation is found to be efficient and its mini-tablets were appropriate for immediate release as compared to Gelucire 50/13 and Poloxamer 188 formulations because of faster drug release that is 100% within 5 min for formulation (F4). There is no considerable alteration in dissolution data on storage at 40ᵒC and 75% relative humidity for three months.

Keywords: Sylysia 350, Gelucire 50/13, Poloxamer 188, Immediate Release, Dissolution efficiency, Mean dissolution time


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