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Abstract

FORMULATION AND EVALUATION OF DICLOFENAC SODIUM TRANSDERMAL PATCHES

S. Chandra*, Naveenkumar D., Mohan Krishnan and Tamilselvan A.

ABSTRACT

The objective of the present study was to develop Diclofenac Sodium Transdermal patches to bypass first pass metabolism and overcome all the problem of conventional dosage forms. A recent approach to drug delivery is to deliver the drug into systemic circulation at predetermined rate using skin as a site of application. The release rate from TDS can be tailored by varying polymer composition. The patches containing 2% diclofenac di-ethanolamine DFD were prepared using Eudragit E100 and poly vinyl pyrrolidone (PVP) as the adhesive polymer by the solvent evaporation technique. The effects of different pressure-sensitive adhesive and various permeation enhancers (Tween- 80, propylene glycol, azone, N-methyl-2-pyrrolidone, menthol) on the vitro percutaneous absorption of diclofenac across rat skin were evaluated using a 2-chamber diffusion cell system. Diclofenac is a NSAID agent used for the treatment of rheumatoid arthritis, osteoarthritis and relief the pain of varying origin treatment. Evaluation parameters like physical appearance, uniformity of weight, thickness, folding endurance, moisture content, drug content, dissolution study and diffusion study are all carried out. The results show that patches of diclofenac sodium obtained by the solvent evaporation method had acceptable physicochemical characteristics and satisfactory % drug release.

Keywords: Diclofenac, polymers, matrix system, adhesives, permeation enhancer, diffusion cell system, polyvinylpyrrolidone (PVP), ethyl cellulose and solvent evaporation technique.


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