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Abstract

FORMULATION AND EVALUTION OF TERBUTALINE SULPHATE BUCCAL PATCHES BY USING HPMC K4M, HPMC E15 POLYMERS

*Middela Karthik and Dr. Reddy Sunil

ABSTRACT

Buccal route of drug delivery is a good alternative, amongst the various routes of drug delivery.[1] Buccal drug delivery is most advantageous because it abundant blood supply in buccal mucosa, bypassing the hepatic first pass effect and accessibility.[2] However, for oral administration of drugs has disadvantages such as hepatic first pass metabolism and enzymatic degradation within the GI tract, that prohibit oral administration of certain classes of drugs especially peptides and proteins. Consequently, other absorptive mucosae are considered as potential sites for drug administration.[3] Oral cavity has been investigated for number of applications including the treatment of periodontal disease bacterial and fungal infection, aphthous and dental stomatitis. Over the last two decades mucoadhesion has become of interest for its systemic delivery by retaining a formulation intimate contact with buccal cavity.[4] The term bio adhesion has been used to define the attachment of a synthetic natural macromolecule to a biological tissue for an extended period of time. When a substrate is a mucosal system adheres and interacts primarily with the mucus layer, this phenomenon being referred to as mucoadhesion.[5] The adhesive properties of such drug delivery platforms can reduce the enzymatic degradation due to the increased intimacy between the delivery vehicle and the absorbing membrane.[6] The use of mucoadhesive polymers in buccal drug delivery has a greater application. Various mucoadhesive devices, including tablets, films, patches, disks, strips, ointments and gels, have recently been developed. However, buccal patch offer greater flexibility and comfort than the other devices. In addition, a patch can circumvent the problem of the relatively short residence time of oral gels on mucosa, since the gels are easily washed away by saliva. Buccal route of drug delivery provides the direct access to the systemic circulation through the jugular vein bypassing the first pass hepatic metabolism leading to high bioavailability.[7]

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