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Abstract

DEGENERATIVE EFFECT OF LEAF EXTRACTS OF CATHARANTHUS ROSEUS LINN. (NAYANTARA) ON HISTOLOGICAL STRUCTURES OF TESTES AND EPIDIDYMIS OF ALBINO RAT

Kartik Shaw, Krishna Nandi, Ramjyoti Ganguly and *Dr. Chandan Roy

ABSTRACT

Male reproductive system is a multifaceted process that involves the
testes, epididymis, accessory glands and associated hormones. Testes
performs two highly organized and intricative events, called
spermatogenesis and steroidogenesis, which are vital for the
perpetuation of life. On the other hand, Catharanthus roseus Linn.
(Nayantara) has an effect on blood sugar. It reduces blood sugar, in
rural areas people often take some leaves of this ornamental plant and
chew it. This project shows that long term use of the leaves of
Nayantara (Nayantara leaf extract) causes reduction in epididymal
sperm count. There was two set of animals having 3 subsets. Main two
sets were before treatment group and other was after treatment group. The subsets were
normal group, low dose group and high dose group. Leaves were collected and water extract
was made and then administered orally to the animals daily for 30 days. After 30 days of
treatment with extract, animals were sacrificed and the parameters were checked. In this
project, it has been seen that Nayantara treatment severely causes lower count of epididymal
sperm, and apoptosis occurred in testes and epididymis cells. Loss of spermatozoa and
destruction of leydig cells seen severely in high dose group animals and moderately in low
dose group animals.

Keywords: Male reproductive system, Catharanthus roseus Linn., Nayantara, Epididymal sperm count, Spermatozoa, Leydig cells.


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