ASSESMENT OF THE ANTI INFLAMMATORY EFFECT OF CINEOL ON CEREBRAL ISCHEMIA REPERFUSION I/R INJURY
Suhad Traiji Zamil*
ABSTRACT
Ischemia and reperfusion in the brain brings a inflammating reaction
that is possibly exacerbating primary stages of tissue wound. This
study has been undertaken to inspect the potential neuroprotective
action of cineol in the improvement of inclusive analytical I/R injury in
rat model via interfering with inflammation. Twenty four adult Swiss
albino rats had been chosen randomly in groups. For 1st group (sham
group), rats endured the similar surgical and anesthesia processes as
the controller group with no bilateral common carotid artery occlusion
(BCCAO). While for 2nd control group (induced-untreated), rats
endured half hour of global cerebral ischemia via BCCAO and then
one hour of reperfusion. For 3rd group (Control – Vehicle), as controller collection but rats
are taken day-to-day the vehicle of 1.8-cineol (10 mL/kg of 2% Tween 80 solution), p.o., then
anesthesia and surgery with BCCAO for half hour followed by reperfusion for 1 hr were
done. For 4th Group (1,8-cineol treated group), the rats received 1,8-cineol. The dose of 1,8-
cineole was 100 mg/kg per oral (po) 1 h before induction ischemia. Then, anesthesia and
surgery with BCCAO for 30 min, followed by reperfusion for 1 hr were done. Compared
with the sham group, levels of IL-6 and TNF-α increased significantly (p< 0.05). The study
results disclose that pretreating process with cineol possibly will enhance the overall cerebral
ischemia-reperfusion injury by anti-inflammatory influence. We concluded that inflammatory
cytokines are involved in global cerebral ischemia due to BCCAO effect. Cerebral ischemia
reperfusion injury can be modified by cineol via its anti inflammatory effect.
Keywords: IL6, TNF-?, inflammation, cerebral ischemia/reperfusion injury, Cineol.
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