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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

A THERAPEUTIC JOURNEY OF SULFONAMIDE DERIVATIVES AS POTENT ANTI-CANCER AGENTS: A REVIEW

Ali Irfan*, Fozia Batool, Shamsha Irum, Sami Ullah, Muhammad Umer, Rabia Shaheen and Amar Jeet Chand

ABSTRACT

Sulfonamide moiety is a core part of many clinical drugs which have broad spectrum applications in the fields of medicine, pharmacology and pharmaceutics such as antibacterial, antiviral, antifungal, antiinflammatory, anti-carbonic anhydrase, diuretic, protease inhibitor, anti-diabetic, anti-cancer, anti-epileptic drug, cyclooxygenase-2- inhibitor, anticonvulsant, receptor tyrosine kinase inhibitors, antitumor and antipsychotic sulpiride etc. This review article focuses on the role of different sulfonamide scaffolds in the treatment of lethal cancer disease on the basis of structure-activity relationship (SAR). The analogs, scaffolds and combinatorial libraries of sulfonamide mentioned in this plethora of research is very helpful for drug discovery and development of novel anticancer therapeutic agents.

Keywords: Sulfonamide derivatives, Anti-cancer, anti-tumor, Pyrimidine, Pyridin, Thiazole, Carbazole.

[Full Text Article]