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Abstract

SIMULTANEOUS ESTIMATION OF OFLOXACIN AND ORNIDAZOLE IN SOLID DOSAGE FORM BY U V SPECTROPHOTOMETRY USING MIXED SOLVENCY CONCEPT

Sanjay Jain*, R. K. Maheshwari, Rajesh Kumar Nema and Indrajeet Singhvi

ABSTRACT

In present research work a new simple, specific, precise, accurate, robust and economical UV-Spectrophotometric method for simultaneous estimation of ofloxacin and ornidazole in tablet dosage form using mixed solvency concept was developed and validated. In the present work 10% sodium caprylate, 10% niacinamide and 10% sodium benzoate blend was used as a hydrotropic solvent to increase the solubility of poorly water soluble ofloxacin and ornidazole. The analytical wavelength for ofloxacin and ornidazole are 330nm and 318 nm respectively. The developed method was validated as per ICH guidelines in terms of linearity and range, specificity, accuracy, precision and sensitivity. The percent drug estimated in tablet formulation was 95.10±0.800 for ornidazole and 97.05±0.530 for ofloxacin by method B. and similarly it was 95.16±0.519 for ornidazole and 100.15±0.300 for ofloxacin by method A respectively. The range of percent recoveries varied from 95.13±0.355 to 95.66±1.07 for ornidazole and 96.82±0.480 to 100.15±0.515 for ofloxacin. Based on the results obtained the proposed method can be regarded a simple, precise, accurate, reliable, cost effective and ecofriendly for simultaneous estimation of ofloxacin and ornidazole.

Keywords: Ofloxacin, Ornidazole, UV-Spectrophotometry, solid dosage formulation, mixed solvency concept.


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