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Abstract

SCREENING OF LEAF EXTRACT OF ARGEMONE MEXICANA FOR IT’S ANTIASTHMATIC ACTIVITY IN ISOLATED GOAT TRACHEAL CHAIN PREPARATION

Raj Tilak1, Sudhir Singh Gangwar, Amita Tilak, R. N. Thakur, Ravindra C. Sutar*

ABSTRACT

The main objective of the work was to evaluate the use of Argemone m exicana (AM) leaves for safety and efficacy in the treatment of asthma. The anti-asthmatic activity of the extract by using different concentraton of methanolic extract at 500,1000 and 1500 μg/ml was evaluated in isolated goat tracheal chain preparations by using standard drug histamine. In the present study, histamine produced dose dependent contraction of goat tracheal chain preparation, as number of papers with antiasthmatic activity are reported with use of guinea pig ileum, tracheal chain preparation but yet antiasthmatic activity was not carried out using tracheal chain hence present study was designed using tracheal chain preparation. The actual dose required to produce bronchodilation was not known so comparison was made by testing various concentration of drug extract of Argemone mexicana. The modified physiological salt solution containing methanolic extract of Argemone mexicana (1.5 mg/ml) significantly inhibited the contractile effect of histamine thus produces significant bronchodilation. It is concluded that 1500 μg/ml of Argemone mexicana showed potent antiasthmatic activity due to bronchodilator activity.

Keywords: Antiasthmatic, Argemone Mexicana, Histamine, Goat Tracheal Chain.


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