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Abstract

SERUM LIPID PROFILE AND NITRIC OXIDE LEVELS IN BETATHALASSEMIA PATIENTS IN HARYANA POPULATION

Monica Verma*, Veena Singh Ghalaut, Alka Yadav, Abhishek Soni and Isha Malik

ABSTRACT

Beta thalassemia is an inherited disorder of blood which has major impact on lipid profile and lipoprotein levels. It is also associated with oxidative stress which can cause premature death due to cardiac complications. This study was planned to assess cardiovascular risk by analyzing lipid profile and nitric oxide levels in Haryana population. The study was conducted on 50 Thalassemia Major patients in age range of 1.5 to 30 years (M: F 32:18) who were receiving regular chelation therapy followed from Thalassemia ward of Pt B D Sharma, UHS, Rohtak. Calcium, phosphorus, NO, TG, TC, HDL-C, LDL-C and VLDL-C of all the subjects were evaluated. Student t tests was used to compare both groups and p<0.05 was regarded as significant and p<0.001 as statistically highly significant. TC, HDL-C, LDL-C and VLDL-C levels in patients with Beta-Thalassemia were found to be significantly lower than those of the control group (p<0.001), while the TG levels were found to be higher (p<0.001). NO levels were found to be significantly lower in cases as compared to controls (p<0.05). Both altered lipid profile and decreased NO levels in beta thalassemia patients suggest an increased coronary risk. As this disease is associated with increased oxidative stress (mainly because of iron overload) which further promotes lipid peroxidation. So, early introduction of iron chelatory agents and antioxidants along with evaluation of cardiovascular risk factors can be beneficial in clinical practice.

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