WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Samir Bhargav* and N. V. Satheesh Madhav


The present work reported an economic approach for SLN development using a Bath-Sonicator. In our method Transmittance (T%) measures the effects of Dextran, Tween 80, Sonication time and Lipid Concentration over formation of Particles below 300 nm. In our brute-force methodology, the modified Solvent-evaporation method has been used for nanoparticle formation. The variables have been optimised using Central Composite Design, to find best SLN formulation with highest T%. The Particle Size analyser has been used for conforming the effect of variables over T% and for supporting our determinations. The Quadratic model from response surfaces for \T%- 300 nm was found significant. The best SLN preparation is made with 0.5-1% Tween 80, 12 mg Dextran, 8 mg LC and 18 min Sonication time. It has maximum T%-300 nm (83.75%) respectively, with Zeta potential as 23 mV. This proposed method can be used for formulating SLNs, along with the determination of Particle size range. The method is economic, by involving a UV Spectrophotometer based approach. Results reveal that there is no insignificant difference between Particle sizes as determined using Spectrophotometer and Malvern Zetasizer.

Keywords: Solid Lipid Nanoparticles (SLN); Central Composite Design (CCD); Transmittance (T%); Lipid Concentration (LC); Sonication Time (ST).

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More