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*Dr. Deepak Mishra, Dr. Praveen Kumar Chaturvedi, Dr. Bibhuti P. Sinha and Dr. Nilesh Mohan


Purpose: To study the role of biological grade cyanoacrylate in perforated corneal ulcers. Methods: This is a Hospital based prospective study on 60 eyes with corneal perforation done at Department of Ophthalmology, IMS, BHU, Varanasi; a tertiary referral centre for ophthalmology. The study was conducted over 14 months of duration. Results: Cases range from 11 years of age to 66 years of age with a male to female ratio of 3:2 The cases reported to our centre as early as 3 days from onset of symptoms to maximum of 38 days from onset of symptoms with a median time interval of 22.5 days between onset of symptoms and the initial treatment. The causative organism or the secondary infection after corneal perforation showed fungal agent (31%) in majority cases. 56.7% of cases had central perforations whereas 43.3% cases had peripheral ulcerations with majority having grade 2 and grade 3 depth of ulceration. The median duration for which cyanoacrylate glue remained on cornea was 43.4 days. Favourable outcome in terms of improvement in visual acuity and healed corneal ulcer was reported in 33.3% cases. Conclusions: Cyanoacrylate glue application in cases of corneal perforations was used to be viewed as a temporary measure in the past, now it can be considered as a definitive therapy in at least half of the patients but with a close monitoring for glue-related complications.

Keywords: Corneal ulcer, Cyanoacrylate glue, Corneal perforation, Glue related complication, Visual outcome.

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