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Abstract

DEPLETION OF OXYTETRACYCLINE FROM CHICKEN TISSUES

Abdelrahman Mostafa*, Nuha M. A. Agbna, Samia A. Wahab and Sania Shaddad

ABSTRACT

Oxytetracycline residue was evaluated in broiler tissues after oral administration of the drug in drinking water. Thirty broiler chickens-4 weeks old age were administered Oxytetracycline in drinking water for five consecutive days at a dose of 200.0 mg/l. Six birds were sacrificed at day 1,3,5,7, and 10 from withdrawal of the drug. Tissue samples from muscle, liver and kidney were collected in plastic containers and stored at –20°C for analysis. The concentration of the drug in different tissues was evaluated using LC-MS/MS. The concentration of the drug in tissues after one day from withdrawal of treatment was121.0μg/Kg in the muscle, 207.0 μg/Kg in the liver and 97.6 μg/Kg in the kidney. From the results of this study in day 1 only the concentration in the muscle (121μg/Kg) was above MRL set by EU. On day 3 the concentration in all tissues was below EU MRL. This study indicates that withdrawal period of Oxytetracycline in broiler chickens could be 3 days, which is similar to that recommended by USFDA.

Keywords: Depletion, Oxytetracycline, LC-MS/MS, chicken tissues.


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