ORODISPERSIBLE TABLETS: A SYSTEMATIC REVIEW
Sachin Gholve*, Amar Kaware, Sanjay Thonte, Dattahari Kaudewar and Omprakash Bhusnure
ABSTRACT
Over the past three decades, orodispersible tablets (ODTs) have
gained considerable attention as a preferred alternative to conventional
tablets and capsules due to better patient compliance, improved
solubility and stability. ODTs are solid dosage forms containing
medicinal substances which disintegrate rapidly, usually in a matter of
seconds, when placed on the tongue. New ODT technologies address
many pharmaceutical and patient needs, ranging from enhanced lifecycle
management to convenient dosing for pediatric, geriatric, and
psychiatric patients with dysphagia. Orodispersible drug delivery
systems are extensively used to improve bioavailability and patient
compliance. This has encouraged both academia and industry to
generate new orally disintegrating formulations and technological
approaches in this field. The aim of this article is to review the
development of ODTs, challenges in formulation, new ODT
technologies, evaluation methodologies, suitability of drug candidates, and future prospects.
Keywords: Orodispersible tablets, Bioavailability, Superdisintegrants, Orodispersible technologies. Orodispersible Drug Delivery Systems (ODDDS).
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