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Abstract

ANTIBACTERIAL EFFECTS OF ETHANOLIC EXTRACT OF SARACA ASOCA LEAVES ON HUMAN PATHOGEN WITH SPECIAL REFERENCE TO ESCHERICHIA COLI AND STAPHYLOCOCCUS AUREUS

D. S. Rathore* and Neha Sharma

ABSTRACT

The ethanolic leaf extracts of Saraca asoca showed significant antibacterial activity against human pathogens i.e. Escherichia coli and Staphylococcus aureus. In the experimental design, the Escherichia coli and Staphylococcus aureus were purchased from the MTCC, Chandigarh. Antibacterial effects of the leaves extract against pathogenic bacteria were evaluated by well diffusion method and resistance of antibiotics against isolates were evaluated by using hexa UTI disc 4 (Himedia pvt limited). Ampicillin, Gentamycin, Nitrofurantoin, Ciprofloxacin, Nalidixic acid, Co-trimoxazole was the antibiotics present in hexa UTI disc-4, tested against E. coli and S. aureus. Now a day, detection of antibiotic resistance against isolates are important for prevention and control of infection. In this study, the ethanolic leaves extract of Saraca asoca were showed greater zone of inhibition comparatively to Ampicillin, Gentamycin, Nitrofurantoin, Nalidixic acid and Co-trimoxazole except Ciprofloxacin. Antibacterial activity of Saraca asoca was due to saponins, tannins, flavanoids, and glycosides. Increasing bacterial resistance against antibiotics is an emerging problem for human health. Therefore, this study was aimed using ethanolic extract of leaves of Saraca asoca and assessing their effect in vitro on bacterial pathogens, and also compared the effect of these extracts with common antibiotics.

Keywords: Saraca asoca, Ethanolic leaf extract, Agar well diffusion method, Antibacterial properties.


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