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Abstract

DESIGN AND EVALUATION OF COMPRESSION COATING PULSATILE DRUG DELIVERY SYSTEM WITH NATURAL AND SYNTHETIC POLYMERS

M. Swetha*, B. Mohan, Dr. J.N. Suresh Kumar, Dr. R. Narshimha Rao, Dr. B. Rama and G. Natesh

ABSTRACT

Aim of the present work is to formulate &evaluate an oral; time controlled pulsatile drug delivery system of Aceclofenac, based on chronotherapeutic approach for the treatment of Rheumatoid arthritis. Aceclofenac is a class of NSAID which is poorly water soluble, used by elders/ Rheumatoid arthritis patients, who may get morning stiffness and joint pains early in the morning. It generally affects the joints and their synovial membranes, cartilages, capsules and the muscles supplying them. Patients with rheumatoid arthritis have pain that usually peaks in the morning and decreases during the day. Chrono therapy for all forms of arthritis using NSAIDs should be timed to ensure the highest levels of drug coincide with peak pain. In present study an attempt made to develop Chrono therapeutic drug delivery system of Aceclofenac with natural super disintegrates in core tablet and natural and synthetic polymers in different ratios as a coating. With pre-determined lag time of 6 hours by compression coating technique.

Keywords: Time controlled pulsatile drug delivery system, Aceclofenac, Rheumatoid arthritis, NSAID, Chrono therapy, super disintegrants, core tablet, natural and synthetic polymers, compression coating.


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