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Abstract

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME SUBSTITUTED-BENZOYL HYDRAZINO DERIVATIVES OF PYRIMIDINE

Darshitkumar M. Dave* and Dr. A. H. Bapodra

ABSTRACT

Pyrimidine constitutes an important class of heterocycles in drug discovery and is very well known for their pharmacological activities. Pyrimidines and their derivatives possess various biological and pharmacological activities. Amides, aryl amides, heterocyclic aryl amides showed widely useful as pharmacologically activities. In vision of above conclusions, it appeared of concentration to synthesize Arylamide (Substituted-benzoyl hydrazino derivatives) of pyrimidine (KLB a-j) by the reaction of methyl-4-(4-fluorophenyl)-2-hydrazinyl- 6-isopropylpyrimidine-5-carboxylate with various substituted benzoyl chloride. The structure elucidation of synthesized compounds has been done on the basis of I.R. and 1H N.M.R. and by Mass spectrometry. Purity of all compounds has been checked by T.L.C.

Keywords: Pyrimidine, Benzoyl Chloride, Hydrazine Hydrate, Aryl amide, Antimicrobial activities.


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