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Neha Jadhav*, Darshana Patil and Rachana Sarawade


Depression is very common mood disorder, which can affect person‟s behavior, feeling & sense of well- being. There are different biological mechanisms such as monoamine hypothesis, hormonal hypothesis, receptor sensitivity, neurogenesis which can causes depression in human. In this review we have targeted the glucocorticoid receptors (GR) which playing main role in depression. The impaired GR signaling may causes the hyperactivity of hypothalamic-pituitaryadrenocortical (HPA) system, resulting in overproduction & secretion of corticotropic releasing hormone (CRH) in various brain region which further leads to cause for depression. Thus, in this article we summarized searching of novel mechanism for depression beyond monoamine hypothesis and the antidepressant therapy which is based on impaired GR signaling as this is also key mechanism for pathogenesis of depression.

Keywords: Glucocorticoid receptors (GR), Hypothalamic-pituitary-adrenocortical (HPA) axis.

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