WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

BCL-2 FAMILY PROTEINS AND CANCER

Farha Fatma* and H. P. Sharma

ABSTRACT

Bcl-2, the founding member of the Bcl-2 family, derives its name from B-cell lymphoma 2. These proteins are localized to mitochondria, smooth endoplasmic reticulum and perinuclear membranes in hematopoietic cells. BCL-2 family proteins are the regulators of apoptosis (programmed cell death) which is required for the removal of infected, damaged or unwanted cells and its disrupted regulation is resulted in cancer, autoimmunity and degenerative disorders. Multiple members of the human Bcl-2 family of apoptosis-regulating proteins have been identified that consists of members that either promote or inhibit apoptosis. BCL-2 proteins have critical roles in normal cell physiology related to neuronal activity, autophagy, calcium handling, mitochondrial dynamics and energetics, and other processes of normal healthy cells. Study in mammals revealed that there is an intrinsic apoptotic pathway that involves the mitochondria and an extrinsic apoptotic pathway that involves death receptors. The mitochondrial pathway of apoptosis in mammals is regulated by members of the Bcl-2 family of proteins. The Bcl-2 family of proteins are key regulators of many, but not all, signals leading to caspase activation. Experimental therapies targeting Bcl-2- family mRNAs or proteins are currently in clinical testing, raising hopes that a new class of anticancer drugs may soon be available.

Keywords: Bcl-2, apoptotic, pro-apoptotic and anti-apoptotic proteins, cancer.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More