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Neha Parveen*, Dr. Roshan Issarani and Anjali Bhardwaj


Periodontal diseases are the conditions that affect the supporting structure of teeth leading to the formation of pocket due to which tooth loss occurs, for which site specific injectable drug delivery systems are gaining importance. The present work investigates the development and optimization of periodontal gel of Cefuroxime Axetil for treatment of periodontal disease. Gel was prepared by using Sodium alginate & Carbopol 934P polymer with different drug/polymer ratios along with PEG 200 & PEG 400. The formulated gel was characterized for surface pH, viscosity, bioadhesion strength, spreadibility, extrudability & in vitro drug release studies. The results revealed that the surface pH was within the range of 6.2-6.5. The viscosity value was ranging from 15860 to 41200 dyne/cm2. Maximum bioadhesion strength, extrudability and spreadibility based on pharmacopoeial limits was found to 6860, 7.75 and 22 respectively. In-vitro drug release showed that initial burst release followed by controlled release pattern showing upto 67.33% in 4 hr. The kinetic analysis of release data revealed that the zero order was the prominent release mechanism. Shelf life of gel was found to 9 months. From the study it was concluded that Cefuroxime Axetil periodontal gel containing polymers with PEG 200 showed more release and good extrudability, spreadibility and bioadhesive strength as compared to PEG 400.

Keywords: Cefuroxime Axetil; Periodontal diseases; Sodium alginate; Carbopol 934P.

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