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Abstract

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF METRONIDAZOLE IN BULK AND TABLET DOSAGE FORM

M. Gayathri Devi*, N. Pravallika Sony, A. C. S. Rupika, I. Indu, B. Vamsi Krishna and G. Rohini

ABSTRACT

A new RP-HPLC method for the quantitative determination of Metronidazole was developed and validated as per ICH guidelines. The drugs were injected into YL-instrument 9300 Model with Hypersil C18 column (250×4.6, 5 μm) maintained at ambient temperature and effluent monitored at 314 nm. The mobile phase consisted of Methanol: Water (50:50 V/V). The flow rate was maintained at 1.0 ml/min. The calibration curve for Metronidazole was linear from 6- 40μg/ml (r2 for Metronidazole = 0.99). The proposed method was adequate, sensitive, reproducible, accurate and precise for the determination of Metronidazole in bulk and pharmaceutical dosage form.

Keywords: Metronidazole, Linearity, Validation.


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