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Abstract

FORMULATION AND CHARACTERISATION OF GASTRO RETENTIVE SUPER POROUS HYDROGELS AN ANTI – RETRO VIRAL DRUG

Annapureddy Madhu Sudhan Reddy, Avanigadda Veenadevi, Tirumalasetty Srilalitha*, Damarla Meghana Murali, Kantamaneni Vasavi, Kosaraju Bhargavi and Palla Hima Bindu

ABSTRACT

Gastro retentive drug delivery is an approach to prolong gastric residence time thereby targeting upper part of GIT for systemic effect. SPHs were originally developed as a novel drug delivery system to retain drugs in the gastric medium for those drugs having absorption window in stomach and upper part of the gastrointestinal tract. The main objective of this work is to prepare and characterize gastroretentive Tenofovir Disoproxil Fumarate superporous hydrogel which is an antiretroviral which are expected to maintain the therapeutic drug concentration in the blood for a prolonged period of time in the gastrointestinal tract. The aim was to increase the permeability and efficacy of the TDF by reducing its side effects. SPHs are prepared by gas blowing technique using various polymers. To characterize the prepared SPH, evaluation tests which include Swelling ratio, swelling time, SEM analysis were performed to know its swelling properties and pores of sph optimized formulation. FTIR studies were carried out to check any possible interactions between the drug and the polymer and study revealed that no interaction between the drug and the polymer. In vitro Dissolution studies were performed to know the drug release from the formulation and it was concluded that optimized formula follows Zero order diffusion and release mechanism follows Higuchi model.

Keywords: Gastro retentive, Superporous hydrogels, Antiretroviral, Tenofovir Disoproxil Fumarate, polymers, Swelling ratio, FTIR – Studies.


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