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Abstract

ANTIMICROBIAL AND ANTIMALARIAL EVALUATION OF SOME NOVEL 2,3-DIHYDRO-4-METHYL-2-THIOXO-1H-IMIDAZOL-5- YL)ETHANONE

Ram Kishore* and Monika Kamboj

ABSTRACT

Novel cyclic thio-urea(aryl or hetero aryl) substituted 2,3-dihydro-4- methyl-2-thioxo-1H-imidazol-5-yl)ethanone derivatives have been synthesized by the amine, CS2 and aqueous NH3, Triton-B and 3- chloro-2,4-pentanedione. These were screened for in-vitro antimicrobial activity against two gram positive (Streptococcus pyogenes and Staphylococcus aureus) and two gram negative bacteria (Pseudomonas aeruginosa and Escherichia coli) as well as for antifungal and antimalarial activity against Plasmodium falciparum strain. Compound 3(d) and 3(g) exhibited good antimicrobial and antimalarial activity.

Keywords: 3-chloro-2,4-pentanedione, amine, CS2, aqueous NH3, catalyst (trimethyl benzyl ammonium hydroxide)Triton-B, Antimicrobial and antimalarial activity.


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