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Abstract

EVALUATION OF CYTOTOXIC ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF ANOGEISSUS LATIFOLIA WITH BRINE SHRIMP LETHALITY ASSAY

Manasi Arjun Bagayatkar* and Vaibhavi N. Garge

ABSTRACT

Cancer is a disease which involves abnormal growth of cells which can proliferate in an uncontrolled way. It can sometimes metastasize to various parts of the body. Natural sources having cytotoxicity can be used to treat cancer. The conventional chemotherapy for malignant tumor is unfavorable because it can lead to various side effects and also is the cause of growing resistance towards various anticancer agents. Therefore, focus has now been shifted from conventional therapy to natural sources to treat various malignancies. Anogeissus latifolia is a plant with potent antioxidant activity. It is also reported to have immune-modulatory, anti-inflammatory, microbicidal, antiulcer, and hepato protective activity, which makes it an ideal natural medicinal source which can be developed as an anticancer agent. Its cytotoxicity has been tested in various human cancer cell lines. The Cytotoxic activity of hydro alcoholic extract of Anogeissus latifolia leaves was investigated for its anticancer potential in vitro using Brine shrimp lethality assay (BSLA). BSLA is a simple, preliminary screening model for bioactive chemicals. It is based on lethality of the test compounds on brine shrimp (Artemia salina). The percent lethality of the brine shrimp in various concentration variations was plotted on a graph, and LC50 was calculated.

Keywords: Cancer, Brine shrimp lethality test, anti-inflammatory.


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