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Abstract

FORMULATION & EVALUATION OF SPHERICAL CRYSTAL AGGLOMERATES OF CANDESARTAN CILEXETIL

Chaubisa Prachi D.*, S. K. Shah and Bhumika Chaudhary

ABSTRACT

A quasi-emulsion solvent diffusion method was adopted for preparation of spherical agglomerates of Candesartan Celexetil using Acetone as a good solvent and water as a poor solvent. Dichloromethane was added to the solution of Candesartan Cilexetil as Bridging liquid. Preliminary trials were taken to identify significant factors affecting formation of spherical agglomerates. A 32 full factorial design was employed to study the effect of following independent variables at the three different levels on the characteristics of the product obtained. They are amount of PVA and amount of PEG 4000. Experimental trials were performed at all possible 9 combinations in and the resultant product obtained was evaluated for parameters like saturation solubility, Hausner ratio, Carr’s index and amount of the drug dissolved in 180 minutes. Based on factorial design analysis, it found that the selected factors having significant effect on % drug release. Tablets prepared by using optimized spherical crystal agglomerates of F4 batch and evaluation done. All physical parameters found within acceptable range. Further the dissolution of tablets in 180 min found more than 90% which was also compared with marketed formulation. The release kinetic model found most satisfactory with Higuchi Model. Stability of spherical crystal agglomerates Tablets of Candesartan Cilexetil found stable after 1 month. Hence, spherical crystal agglomerates of Candesartan Cilexetil successfully prepared by quasi-emulsion solvent diffusion method and solubility improved. Further based on the results,

Keywords: Spherical crystal agglomerates, Candesartan Cilexetil.


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