Abstract

DESIGN AND EVALUATION OF BILAYER SUBLINGUAL DRUG DELIVERY FOR ASPIRIN AND ISOSORBIDE MONONITRATE: A REVIEW

Jalaj Kumar Nishad, Suchita Wamankar*, Gyanesh Kumar Sahu

Abstract

In order to reduce myocardial damage and restore coronary perfusion following an acute myocardial infarction (AMI), antiplatelet and vasodilatory action must begin quickly. The sublingual method is appropriate for emergency medication delivery, avoids first-pass metabolism, and offers rapid systemic absorption. An new drug delivery strategy for dualaction therapy of ischemia episodes is the use of bilayer sublingual tablets that combine isosorbide mononitrate (ISMN, controlled or sustained-release) and aspirin (immediaterelease). The pathophysiological basis of AMI, the need for sublingual drug administration, important excipients, formulation techniques, assessment criteria, and current developments in bilayer delivery systems for cardiovascular emergencies are all summarized in this brief study.

Keywords: Myocardial Infraction, Sublingual Drug Delivery, Cardiovascular, Aspirin and Isosorbide Mononitrate.