Abstract

TO EVALUATE THE EFFECTIVENESS OF INTRATYMPANIC STEROID INJECTIONS IN SUDDEN SENSORINEURAL HEARING LOSS

Dr. Hadiya Iram*, Adapala Haritha Reddy, Chepuri Deepika, Sidra Najam

Abstract

Journal │ Iram et al. World Journal of Pharmaceutical Research 1362 TO EVALUATE THE EFFECTIVENESS OF INTRATYMPANIC STEROID INJECTIONS IN SUDDEN SENSORINEURAL HEARING LOSS Dr. Hadiya Iram*1, Adapala Haritha Reddy2, Chepuri Deepika3, Sidra Najam4, Mahveen Begum5, Sreemantula Divya6, Dr. Ashok Prudviraju Moganti7 1Assistant Professor, Department of Pharm. D, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya (CO-ED.), Tarnaka, Hyderabad, Telangana, India - 500017. 2,3,4,5Pharm. D V Year, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya (CO-ED.), Tarnaka, Hyderabad, Telangana, India - 500017. 6Assistant Professor, Department of Pharmacy Practice, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya (CO-ED.), Tarnaka, Hyderabad, Telangana, India - 500017. 7MBBS, MS (ENT), Consultant ENT, Head and Neck Surgeon, Medicover Hospitals, Madhapur, Hyderabad, Telangana, India -500081. ABSTRACT Sudden sensorineural hearing loss (SSNHL) is a rapid-onset condition characterized by unexplained hearing loss, often occurring within 72 hours. The aim and objectives of the study to evaluate the effectiveness of Intratympanic Steroid (Methyl Prednisolone) Injections in Sudden Sensorineural Hearing Loss. The objective of the study to check the safety and tolerability of Intratympanic Steroid (Methyl Prednisolone) Injection in Sudden Sensorineural Hearing Loss. The study was desigined a Prospective, Comparative, Observational, Single Centre Study, it conducted in the deprtment of ENT at Medicover Hospitals, Hitech city, Hyderabad, in the periodof 6 months with population size was 25 patients. The result of the study on 25 population has Analysis by Intratympanic methylprednisolone (40 mg/ml), administered as 0.5 ccf via direct injection into the middle ear once a month for three consecutive months, patient-based outcomes revealed that 22 patients (88%) showed significant hearing improvement, while 3 patients (12%) showed no improvement. The procedure was well-tolerated, with minimal and transient side effects such as mild pain at the injection site (3 patients, 12%), dizziness (3 patients, 12%), and ear fullness (3 patients, 12%), while 16 patients (64%) reported no adverse effects. The study concludes that Intratympanic methylprednisolone injection is an effective, safe, and well-tolerated treatment for SSNHL, providing significant improvement in hearing outcomes with minimal adverse effects, and can serve as a primary or salvage therapy in the management of SSNHL.

Keywords: SSNHL, Allergic rhinitis, Intratympanic methylprednisolone, Ear, 72 hours and prospective.