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Meenu*, Hina Chadha and Sokindra Kumar


Epigenetics, is the study of changes in gene expression but do not involve changes to the DNA sequence which in turn affects how cells read the genes. DNA methylation is also the process where the addition of a methyl group to part of the DNA molecule, which prevents certain genes from being expressed. Epigenetics also works through the histone modification, Acetylation of specific lysine residues on core histones is believed to result in uncoiling of the DNA. There are various diseases, including cancer, heart disease, diabetes, and mental illnesses are influenced by epigenetic mechanisms, and epigenetic therapy offers a potential way to influence them directly. When genes are silenced, their expression is reduced. Epigenetics play a major role against nephropathic and diabetic nephropathic conditions via epigenetical modifications in the specific genes.

Keywords: DNA methylation, histones, uncoiling, diabetic nephropathy.

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