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Abstract

A REVIEW: FACTORS AFFECTING DISSOLUTION OF BCS CLASS II DRUG

Bidkar S. J., Kadam D. M.*, Dama G. Y. and Bidkar J. S.

ABSTRACT

Pharmaceutical products exists in the form of different dosage forms such as oral solid dosage form, oral semi-solid dosage form, oral liquid dosage form, injectable, etc. Solid dosage form contributes to more than 40% of the pharmaceutical products primary reasons for preference being ease of administration, ease to identify and relatively acceptable taste. Pharmaceutical solid dosage form on administration undergo dissolution in biological media, followed by absorption of the drug entity into the systemic circulation. Two drug products containing the same active substance are considered bioequivalent if their bioavailability (rate and extent of drug absorption) after administration in the same molar dose lie within acceptable predefined limits. The insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability of poorly water soluble compounds. The purpose of this review article is to provide overview of dissolution and describe the factors affecting dissolution of BCS class II drug.

Keywords: Oral solid dosage form, Dissolution, solubility, BCS class II drug, poor water solubility.


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