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Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF NISLODIPINE USING DIFFERENT SUPERDISINTEGRANTS

B. P. Parameshwara*, Md. Rajdar, Dr. Mekkanti Manasa Rekha, Dr. Rinku Mathappan and K. Rekha

ABSTRACT

Hypertension (HTN) is one of the most important risks for Cardiovascular Disease, Stroke, Myocardial Infarction and end stage of Renal Disease. Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage gated L- type calcium channels in their inactive conformation. By inhibiting the influx of Calcium in smooth muscle cells. The fast dissolving drug delivery system was chosen as the route of administration with an aim of overcoming the above mentioned difficulties. Dysphagia in Hypertension (HTN) patients is most commonly of infectious etiology. It is the medical term for the symptoms of difficulty in swallowing. Considering above clinical manifestation associated with HTN, a fast dissolving drug delivery of the proposed drug can prove to be beneficial in treating such conditions effectively. Pre formulation studies have confirmed purity of drug, lipophilicity and compatibility of drug with excipients used in the formulation of mouth dissolving tablets. Pre-compression studies have confirmed stability of formulation blends for compression. Superdisintegrants viz. natural and synthetic were screened to obtain quick disintegration time. Formulation F18 containing mango peel powder at concentration 6% was found to have disintegration time of 18.12±0.13sec, wetting time35.19±0.58 sec. In-vitro studies of F18 indicated 98.916% of drug release in 45 min. Optimized formulation was found to be stable after 3 months accelerated stability studies. Hence with the proposed method, elegant MDTs of drug could be successfully formulated that would help improve the patient compliance.

Keywords: Hypertension, Nisoldipine, Dysphagia, Mdts.


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