WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION DEVELOPMENT AND CHARECTERIZATION OF NOVEL PREDNISONE MUCOADHESIVE LIPOSOMAL FORMULATION

Parthiban S., Priyanka Raj G.* and Senthil Kumar G. P.

ABSTRACT

The aim of the present investigation was to design a mucoadhesive liposomes containing Prednisone. Liposomes were prepared by the thin film hydration method by using chloroform as a solvent. Mucoadhesive liposomes containing prednisone formulations were prepared by different concentration of lecithin and cholesterol by thin film hydration technique. These formulations were evaluated for entrapment efficiency, particle size, zeta potential, surface morphology and in-vitro drug release. Particle size and zeta potential of the F4 formulation was found to be 212 nm, -164.9 mV respectively. Coating of liposomes resulted increase in particle size and also increases the zeta potential. Highest entrapment efficiency was observed in F1 and F3 92% and 94%. The percent drug release from F1-F4and CF1 was observed as follows F1- 88.57%, F2-73.31%, F3-76.29%, F4-90.97%, and F1 coated as a CF1-69.85%. Release kinetics follows the Higuchi plot and non-Fickian diffusion mechanism.

Keywords: Predisone, mucoadhesive liposome, thin film hydration method, in-vitro release.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More