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Abstract

PREPARATION AND CHARECTERIZATION OF PRONIOSOMAL DRY POWDER INHALER OF BUDESONIDE USING LACTOSE CARRIER FOR NASAL ADMINISTRATION

S. Parthiban, Pradeepa N.* and G. P. Senthil Kumar

ABSTRACT

Current asthma therapy is direct at reducing pulmonary inflammation through use of anti-inflammatory drugs, such as inhaled corticosteroids. However, the need for daily administration of inhaled steroids might lead to patient noncompliance and treatment failure. In addition, inhaled steroids have a short half-life in vivo and potential toxicity if higher doses are used. Budesonide is a corticosteroid used in the prophylactic management of asthma, Budesonide is a hydrophobic compound and highly insoluble, demonstrating low bioavailability. But, Proniosomal encapsulation of Budesonide can controls the release of drug and increases the solubility of drug in its hydrophobic core and maintains therapeutic concentration of the drug in the lungs for longer periods. The present investigation was aimed to develop proniosome encapsulated Budesonide as DPI using lactose as carrier. Developed formulation were compared in terms of morphology, SEM, vesicle size, XRD, entrapment efficiency and in vitro drug release. Budesonide used as model drug. Average particle was maximum number of particle lies in the range of 292.4-334.0 nm in presence of for lactose. Percentage cumulative drug release was higher in FA4 formulation while entrapment efficiency was less in FA2, FA3 compare to FA4. The effect of parameters have been studied by using 2x 2 factorial design using QI macros R DOE software

Keywords: Proniosome, Lactose, Budesonide, asthma.


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