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Abstract

NEUROPROTECTIVE EFFECT OF HESPERIDIN IN LIPOPOLYSACCHARIDE INDUCED MEMORY IMPAIRMENT MODEL OF ALZHEIMER’S DISEASE

Mohan Lal, Pawankumar Rai, Manik Bainwad, Afroj Shaikh, Archana Ramesh Juvekar*, Malvika Gurvashi and Nitin Gawali

ABSTRACT

Alzheimer’s disease (AD) is a modern neurodegenerative disorder with a range of memory, learning, behavioral abnormalities. The objective of the present study was to evaluate the neuropharmacological effect of hesperidin, a flavanone group member in memory impairment model of AD. Lipopolysaccharide (LPS, 0.25 mg/kg, i.p.) was employed as an experimental amnesia inducing agent. The animals were divided into five groups containing eight animals each. The tested dose of hesperidin (100 and 200 mg/kg, p.o.) significantly improved the learning ability and retention of learned memory in behavioural parameters such as Y maze spontaneous alteration and morris water maze test. Moreover, the neuroprotective effect of hesperidin was well supported by histopathological examination of hippocampus of brain, wherein the severity of cell damage and degree of neuronal cell death was less comparative to LPS group. This study suggests a potential neuroprotective role of hesperidin against LPS-induced AD like manifestations.

Keywords: Neurodegeneration, Lipopolysaccharide, Hesperidin, Memory impairment, oxidative stress.


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