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Abstract

CLINICAL ASSESSMENT OF COGNITIVE IMPAIRMENT IN VARIOUS CONDITIONS OF HYPOTHYROIDISM PATIENTS

S. Anandkumar* and S. Venkatesh

ABSTRACT

Aim/objective: To assess the cognitive impairment in various
conditions of hypothyroidism patients. To investigate MMSE score in
hypothyroid and euthyroid subjects to explore the relationship between
thyroid dysfunction and cognition. To assess the MMSE score on the
mood and cognitive changes associated with subclinical
hypothyroidism (SCH). To assess the MMSE score on the mood and
cognitive changes associated with overt hypothyroidism. To explore
the association between education status of the patients with MMSE
scores. Methods: It was a cross sectional observational case control
study. Result: The average MMSE score of hypothyroid patients was
22.56±3.36, average MMSE score of control group is 24.94±2.48 (**p
<0.0001). The average MMSE score of subclinical hypothyroidism
patients was 21.93±2.93, average MMSE score of control group is 24.94±2.48 (*p<0.001).
The average MMSE score of overt hypothyroidism patients was 23.32±3.72, average MMSE
score of control group is 24.94±2.48 (*P<0.0031). Conclusion: Present study indicating
hypothyroidism patients have low MMSE score than euthyroid participants which reveals
hypothyroidism is significantly associated with cognitive impairment. Our finding reveals
that SCH was significantly associated with mild cognitive impairment more research is
required to determine the nature and extent of this association. Present study also reveals the
association between overt hypothyroidism and mild cognitive impairment. Our finding shows
that SCH have higher risk of cognitive impairment than overt hypothyroidism in this sample.
Present study also reveals patients who have chronic thyroid damage leads to higher risk of
cognitive impairment.

Keywords: SCH, overt hypothyroidism, MMSE, cognitive impairment.


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