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Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF PHENYLEPHRINE HYDROCHLORIDE, CAFFEINE, PARACETAMOL, CHLORPHENIRAMINE MALEATE IN PHARMACEUTICAL DOSAGE FORM USING METHOD OF LEAST SQUARES BY USING ULTRA VIOLET SPECTROPHOTOMETER

P. Sreemahalakshmi, S. Hemanth Reddy, CH. Veena, SK. Nowshin, P. Divya, B. Sahithya* and Dr. K. Harinadha Baba

ABSTRACT

A simple UV-Visible spectrophotometric method was developed for the determination of phenylephrine hydrochloride, caffeine, paracetamol, chlorpheniramine maelate in pure and its pharmaceutical formulation. They exhibited maximum absorption at 220nm for phenylephrine hydrochloride, 215nm for caffeine, 250nm for paracetamol and 205 nm for chlorpheniramine maelate. The following drugs obeyed linearity in the range of 1-25μg/ml for phenylephrine hydrochloride, 1-50μg/ml for caffeine, 1-5μg/ml for paracetamol and 10-60μg/ml for chlorpheniramine maleate. The proposed method was statiscally evaluated. All the proposed methods are simple, selective, reproducible, sensitive, and accurate with good precision. The selected solvent was water for the dosage form. The proposed methods can be used as an alternative methods to the reported ones for the routine determination of selected drugs under the study in bulk and pharmaceutical dosage forms.

Keywords: Phenylephrine hydrochloride, Caffeine, Paracetamol, Chlorpheniramine maelate, UV-Visible spectrophotometer, Least squares.


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